PSY 3061 Lecture Notes - Lecture 20: Amyloid, Grid Cell, Thiamine

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Taxonomy of long term memory: long term memory a. Implicit memory -> habituation/sensitization, motor learn, emotional conditioning, habits: explicit -> semantic, episodic. Implicit: priming: neocortex, procedural habits: striatum, emotional: amygdala, motor learning: cerebellum, habituation: reflex pathways, spinal chord. Retrograde amnesia- cannot remember events prior to brain damage. Anterograde amnesia- cannot later remember events that occur after brain damage (no new memories) The case of h. m. : severe, intractable epilepsy, surgery- bilateral medial temporal lobectomy. Hippocampus: developed severe anterograde amnesia, normal working/implicit memory. Block-tapping memory-span test: first case to implicate hippocampus for memory information, short term/long term memory are distinct capacities, distinction between explicit/implicit memory, distinction between types of amnesia"s (consolidation) Longterm potentiation (in hippocampus) required for memory: only happens when excitatory post synaptic reaches maximum, dependent on ltp, hippocampus injured= new information impossible, learning/memory are dependent of each other. The case of r. b: heart surgery, less severe amnesia that h. m, ischemia -> brain damage, ca1 hippocampal layer- long term potentiation.

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