LAMP 4177 Lecture Notes - Lecture 1: Systemic Lupus Erythematosus, Foreign Body, Thyroiditis

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Autoimmunity a reaction of the person"s body to their tissues. 5-7% of the population are affected by autoimmunity over 40 types of autoimmune diseases. Types of autoimmunity: humoral autoimmunity (antibody, cellular autoimmunity (ex. diabetes, organ specific autoimmunity. Most organ speciic disease = hashimoto"s thyroiditis: stomach, pancreas, adrenal. Non organ speciic autoimmunity: muscle, kidney. Least organ speciic disease = systemic lupus erythematosus (sle: skin. *immune system must be able to differentiate between self antigens and foreign body antigens. -positively select t cells that recognize non self. -involves cd4, cd8, &thymoctyes in the developing fetus. -involves tcr recognition of self peptides bound to self mhc. -may relate to different antigens in presenting cell. Ways self reacting t cells can be controlled: clonal deletion -thymocytes are killed in the thymus gland, clonal anergy, suppression, apoptosis. Principles of self tolerance, needs to be balanced against the ability to recognize foreign antigens. Early decalciication around the joints = early diagnostic tool.

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