BMEN 2501 Lecture Notes - Lecture 4: Antigen, Adaptive Immune System, Plasma Cell

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15 Sep 2016
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Bmen 2501 lecture 4 notes from 9/14/16 on ch 4. Includes: antibodies, their structure, characteristics, immune response, and other uses. Structure: includes heavy chain and light chain domains, all antibodies have the long domain at the base, top branches out to look like hands which is part of the hypervariable region. This region changes with every cell that makes that antibody: cells that make antibodies are b-cells which make up lymphocytes, the primary cells of the adaptive immune system. The part that recognizes specific molecules and responds. B-cells: primary responders of the adaptive immune system, transform into plasma cells when they encounter new antigens prior to transcription. The plasma cells morph out, stop proliferating, and start producing antibodies that will bind to that specific antigen at a certain spot: once a b-cell becomes a plasma cell, it only makes that specific antibody. More b-cells come from the bone marrow to replace the others.

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