BIOLOGY 151 Lecture Notes - Lecture 6: Phosphatase, Moodle, Growth Factor
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The 2nd perusall assignment on topic 2 reading (pg. 1-19 of pdf) is due tonight at 11:59pm. I"ve posted the 3rd perusall reading (topic 2: cell cycle and cancer biology) due sept. 30th midnight. Reivew session with undergrad ta tomorrow night (thursday) at 7:30pm in morrill iii 203. Moodle pre-lecture assignment 3 is open and due sunday night (on topic 3 cell cycle) Rtk/ras/mapk pathway: outcome changes in which genes are expressed, receptors. Receptor tyrosine kinases (rtk) class/type of receptors. Cells can have more than one of this type of receptor. Rtks have 3 parts: receptors outside the membrane, transmembrane region anchored in the cell membrane, tyrosine kinase inside the cell. Most rtk pathways involve growth factor, survival, insulin, self-renewal signaling. Signal binds to receptors, which cause them to come together, also called. When two proteins come together to form a functional unit. Dimerization causes auto phosphorylation aka cross phosphorylation. Intermolecular interaction kinase phosphorylates another kinase of its own type.
