MCDB 310 Lecture Notes - Lecture 22: Malonyl-Coa, Fatty Acid Synthase, Acetyl-Coa

• School: U of M
• Department: Molecular, Cellular and Developmental Biology
• Course: MCDB 310
• Professor: Kenneth Balazovich

Document Summary

Glycerolphospholipid synthesis preview: make 16 carbon fatty acid chains (palmitic acid product, lengthen acyl chain if necessary, desaturate acyl chain if necessary, add glycerol backbone (phosphatidic acid product, add head group. It is highly regulated to prevent futile cycling: lipid synthesis and lipid oxidation (beta oxidation) use different enzymes in different pathways in different parts of the cell. Overview of the four repeated steps: step 1: condensation of activated acyl group and 2 carbons from malonyl- Regulation of fatty acid biosynthesis: allosteric regulation of acetyl-coa carboxylase (enzyme that converts acetyl-coa + bicarbonate into malonyl-coa, want this enzyme to be regulated because making malonyl-coa is the first input of. Atp/energy into the synthesis process and by regulation that you slow down everything before building up intermediates: this is the rate limiting step in fatty acid biosynthesis so it is important to regulate, 1. Palmitoyl-coa is a feedback inhibitor that inhibits malonyl-coa synthesis: 2.