MCDB 310 Lecture Notes - Lecture 14: Active Transport, Glucose Transporter, Gluconeogenesis

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Amylase starts breaking down complex carbs into sugars in your saliva/esophagus. Acidification in stomach (chief cells) ph goes down and proteolytic enzymes turn on to cut bonds between amino acids (acid hydrolysis) In small intestine, there is alpha-amylase and breaks down oligosaccharide into individual sugars. Pull carbs down into the intestine and k+/na+ atp and leave low sodium concentration in - epithelial cells, and is pulling glucose against its concentration gradient because sodium is going with its concentration gradient (only one pathway) Feeder pathways: other sugars can feed indirectly into glucose. In general, all sugars are being transformed into g6p, f6p or g3p and feed into glycolysis: keeps glycolysis going and all consequent reactions. Chapter 15 & 20: regulation on carbohydrate metabolism. Glucose mobilization: need regulation of glucose transport. If we have glucose coming out, can have it going into the blood (too much could be harmful: glycogen to g1p indirectly enters glycolysis through phosphoglucomutase reaction.

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