KN 252 Lecture Notes - Lecture 3: Hematopoietic Stem Cell, Erythropoiesis, Proerythroblast
Document Summary
Components of the blood plasma and formed elements. Blood functions: transportation/distribution of substances, maintenance of homeostasis temperature regulation; chemical buffering/ clotting mechanisms to maintain normal general function, protection immunity. Three components: proteins and lipids albumin, globulins, fibrinogen (clotting proteins, dissolved components ions, gases, glucose, serum no clotting proteins (it"s just plasma with all components except for the clotting proteins) Plasma maintenance (two parts): fluid maintenance (to maintain volume) consumed and removed (input = output, maintenance of solutes liver, kidney, intestine, endocrine gland, immune tissues. The kidney secretes erythropoietin (hormone that stimulates stem cell) The kidney is very sensitive to low levels of o2 in the blood. When o2 in blood drops, the kidney release more erythropoietin so that more rbc"s will be produced. Transport co2 from the tissues to the lungs. After birth: occurs in bone marrow and lymph tissue. Anemias: few rbc"s; decrease hemoglobin content; abnormal hemoglobin.
