MCB 150 Lecture Notes - Lecture 7: Bone Resorption, Osteoid, Osteoblast
9 Jan 2019
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Skeletal system: bone structure and function - (9 questions) Section 7. 2e - cells of bone; comparison of compact and spongy bone. Section 7. 6 - parathyroid hormone, calcitriol and calcitonin. 9 questions: know the specialized cells found in bone (osteoprogenitor cells, osteoblasts, osteocytes, osteoclasts) as well as their functions. Osteoprogenitor cells : stem cells derived from mesenchyme, precursor to bone cells. Divide into one stem cells and one committed cell that becomes an osteoblast. Osteoblasts : positioned side by side on the bone surfaces. Usually have abundant rough er and golgi. Synthesize and secrete initial organic form of bone matrix (osteoid) Once osteoblasts are entrapped by the matrix they produce (mineral deposition by osteoid), they differentiate into osteocytes. Osteocytes : mature bone cells derived from osteoblasts that have lost bone-forming ability. Maintain bone matrix and detect mechanical stress on the bone and signal osteoblast for new bone matrix surface.
