SOC 3382 Lecture Notes - Lecture 22: Acetylcholine, Nucleus Accumbens, Cerebral Cortex
12 Nov 2020
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Document Summary
Mesolimbic dopamine pathway: from the ventral tegmental area in the midbrain to the nucleus accumbens, proposed to mediate some types of psychotic behavior, possible component of the rewarding properties of drugs. Nigrostriatal dopamine pathway: from the substantia nigra to the striatum, past the hypothalamus, substantial loss of cells leads to parkinson"s disease. Acetylcholine: pathways arise from cell bodies in the nucleus basalis in the lower part of the brain and project widely throughout the cerebral cortex. Involved in alzheimer"s disease: acetylcholine blockers impair memory. Norepinephrine pathways: arise from the locus ceruleus in the brain-stem and project both up and down in the brain. Influence the level of arousal and attentiveness: play a role in the initiation of food intake. Serotonin pathways: arise from the brain-stem raphe nuclei and project both upward into the brain and downward into the spinal cord, may have a role in impulsivity and aggression, depression, food intake and weight control, and alcohol use.
