BIOL 3324 Lecture Notes - Lecture 16: Prostacyclin, Antithrombin, Factor X
17 Nov 2016
School
Department
Course
Professor
Document Summary
Lecture 16: intrinsically triggered: everything for clotting is already in the blood. Initiated via damage within the vessel: extrinsically triggered: factors external to blood are required. Damage outside of the vessel initiates this. The common clotting pathway: prothrombinase prothrombin thrombin, thrombin fibrinogen fibrin, thrombin factor xiii xiiia. Xiiia links fibrin monomers to make a polymer to make a mesh. Positive feedback to prothrombin, factor v va, factor viii . To release no, pgi2: prevent platelet aggregation at sites other than the site of injury, no= inhibit platelet adhesion and aggregation, pgi2= vasodilation, increase blood flow, inhibit platelet activation. Release adp, vwf activate platelet aggregation. To keep the pathway in check: no, pgi2, anticoagulants. Fibrinolysis= destruction of a blood clot: convert plasminogen to plasmin, after thromodulin binds to thrombin. Via tpa or upa (urokinase type plasminogen activator) The vascular tree: arteries= blood away from heart. Have a lot of resistance due to their small radius.
