BIOL 1344 Lecture Notes - Lecture 17: Renal Function, Renal Physiology, Juxtaglomerular Cell
14 Sep 2016
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Angiotensinogen > angiotensin i > angiotensin ii > vasoconstriction; low gfr restored to normal. Na+, k+, cl-, hco3-, po4 -3, so4 -2, ca+2, h2o, Renal failure > lose proteins in urine: albuminuria. Tubular reabsorption: 99-99. 5% of filtrate is reabsorbed. H+, so4 -2, po4 -3, antibiotics, creatinine, urea. Gaps called filtration slits between foot processes of podocytes. Myogenic control: smooth muscles of afferent arteriole > Tubuloglomerular control: macula densa cells of dct (neck segment) >na+ conc. of filtrate. High conc. filtrate (gfr is too high) > gfr is decreased. Low (gfr is too low) > gfr is increased. Epinephrine > binds to beta2 receptors: vasodilation > gfr increases. Epinephrine > binds to alpha 1 receptors: vasoconstriction > gfr decreases. Both regulated: gfr increased or decreased depending on need. Renal clearance: how much plasma is cleared of a substance. [urine conc. (mg/ml) x urine flow (ml/min)]/plasma conc. (mg/ml) Indication of kidney function [egfr: effective gfr]
