BCHS 3304 Lecture Notes - Lecture 15: Alcohol Dehydrogenase, Redox, Enzyme
17 Nov 2016
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Enzyme= protein that has catalytic properties: help reactions occur at a faster rate, lower activation energy. 10^6- 10^ 14 times faster: milder reaction conditions. Neutral ph, low temp, atmospheric pressure: they are very specific for their substrate. Binding pockets can be pre-formed: can undergo adjustments, (cid:498)induced fit(cid:499) Enzymes are made of a chiral aa. Even if substrate is achiral chiral product: they can be regulated. Allosterically, covalent modification, variation in protein expression: nomenclature. Add (cid:498)-ase(cid:499) to the end of the substrate that is acted upon or. Thus, describes the reaction that is catalyzed. Alcohol dehydrogenase catalyze oxidation of phrase that describes reaction: 6 major categories alcohols to make them into aldehydes. Addition of atp: cofactors= expand range of enzymatic reaction. Apoenzyme= removal of cofactor, makes it inactive: catalytic mechanisms. If acts as base initially, will later act acid. Ex: rnaase a: his 12= acts as base initially. Abstracts a proton: his 19= initially acts as acid.
