POUL 3000 Lecture Notes - Lecture 2: Prostacyclin, Autocrine Signalling, Paracrine Signalling

• School: University of Georgia
• Department: Poultry Science
• Course: POUL 3000
• Professor: Benson

Document Summary

Histones are supposed to be inside the cell. Therefore, when they are released outside the cell, this is an indication that there has been severe damage. Damp/pamps- macrophages/dendrites will secrete vasoactive amines (serotonin & histamine). Vasodilation causes blood cell components to more along edges of endothelium. Meanwhile, we will get cytokines- activated macrophages in the tissue release cytokines such as il-1 (interleukin 1) and tnf (tumor necrosis factor) bind to their respective g protein- coupled receptors on the endothelial wall. Heterophils secrete chemokines to attract macrophages come in and clean up all that stuff: lymphocytes are last on the scene. Takes a while for them to build up because they have to be tested first- have to have the right t cell or b cell to match up with that pathogen. Need to enhance its adhesion via a high affinity integrin. Needs to be exposed to cytokines which will generate high affinity integrin"s.