CBIO 3400 Lecture Notes - Lecture 3: Cyclin A, Cyclin E, Dna Replication
20 Apr 2019
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What are cyclins & cdk"s: different cyclins act at different stages of the cell cycle. However, when they encounter their cyclin counterpart, they become active: m-cdk triggers mitosis machinery, s-cdk triggers dna replication machinery. Cell cycle control systems: because these are kinases what do we suppose they are doing to move the cell cycle forward, they are kinases, so they phosphorylate and modulate things as they move through the cell cycle. Cyclins are what are the targeting domains and activating domains. The cdk"s are more for general purpose phosphorylating machines. Ways to think about them: how enzymes select their substrate, a, b. *proteins will build in secondary regions on them to be able to find the specific substrate they want to modify. Cdk are active regions and cyclins help target cdk to target region. Cyclins are the adaptor modules that allow you to direct cdks. 2 kinase and a phosphatase in this system.
