CBIO 3400 Lecture 8: CBIO 3400
23 Jan 2019
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Increase or decrease in second messengers: example: camp. G-proteins: active in gtp-bound form b/c of arrangement that occurs in gamma phosphate presence, phosphate groups are very negative. When phosphate group is present, that phosphate interacts with groups on the switch 1 and switch 2 regions. Backbone of glycine and thr, those are brought together and can act upon downstream proteins and turn them on. Inactive in gdp-bound form: lack phosphate group to coordinate the two switch groups, so they separate. G protein isn"t active; won"t be able to turn on any downstream products. Proteins that affect g-proteins: guanine-nucleotide exchange factors (gefs)* Induces a conformation: results in binding to gdp. Beta-adrenergic signaling pathway: adrenalin = epinephrine, causes fight or flight response. Increase atp: mobilizes the body"s resources for energy, binds adrenergic receptors, alpha-adrenergic receptor g1, beta-adrenergic receptor gs. Involves a stimulatory g-protein, called gs: s stands for stimulatory, effects on hepatocytes (liver cells, stimulates breakdown of glycogen, effects on adipose cells.
