PCB 3063 Lecture Notes - Lecture 18: Non-Coding Rna, Epigenome, Methylation

• School: University of Florida
• Department: Process Biology
• Course: PCB 3063
• Professor: Bond

Document Summary

Lecture 18: beginning of class announcements: there will be no curve on the exam, and make sure to start working on the poster projects. Recall that you"ll have to rank group member"s contributions: complete the end of course evals when they come out, and dr. Prader-willi (pigmentation and insatiable appetite), angelman (hyperactivity, characteristic smile), beckwith-weidemann syndrome (really large tongues: this is an up-and-coming field. If the epigenome is not regulated correctly, it can lead to disorders. Major groove: dna methylation patterns are passed onto daughter strands through methyltransferase, or dam methylase, methylation is common in heterochromatin, example is in the centromere and the telomere ends of chromosomes. These can be on autosomes: methylation usually occurs before fertilization takes place, and that type of imprinting ignores the type of epigenetic reprograming that happens after fertilization, regulatory rna"s, microrna"s are really important to silencing genes.