PCB 3063 Lecture Notes - Lecture 3: Familial Hypercholesterolemia, Sickle-Cell Disease, Wrinkle
17 Dec 2018
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Chapter 3 medelian genetics: why do we care about genetic ancestry, many human traits and diseases have genetic origins, many of which have. Mendelian inheritance patterns: 1/13 african americans are carriers of sickle cell disease; carriers have sickle cell trait and show little effect, cystic fibrosis: 1/29 caucasian americans are carriers, 1/45 of hispanic. Americans, and 1/65 african americans: 1/250 worldwide have familial hypercholesterolemia, essentially there are a lot of people who have genetic risks of being a carrier of these traits. Important vocabulary: genotype: specific alleles of genes in dna; combination of alleles for a trait; Round produced round and wrinkle produced wrinkled. When crossing a round vs. wrinkle, he found all round in the f1 generation. When the f1"s were crossed with each other the wrinkled traits reappeared. Of f2 were round and were wrinkled. The traits, in other words, did not blend.
