HUN 4221 Lecture Notes - Lecture 14: Blurred Vision, Liver Biopsy, Natural Killer Cell

• School: University of Florida
• Department: Food Science and Human Nutrition
• Course: HUN 4221
• Professor: Mitchell D Knutson

Document Summary

11-cis-retinal and shuttled to rod cell if needed. Immune system: deficiency results in multiple abnormalities in innate and adaptive immunity involving, cell differentiation, hematopoiesis, blood and lymphoid organ cell populations, ability to respond to pathogens, antigens. Increased and decreased in number of function of: b cells, t cells, natural killer cells, antigen-presenting cells, macrophages, antibody responses to t cell-dependent antigens, maintaining integrity/function of mucosal surfaces. Increasing lymphocyte proliferation responses to antigens: upregulated expression of mrna by retinoic acid for mucin proteins of respiratory tract, dermatology, epithelial tissue is sensitive to deficiency as well as xs vitamin a, synthetic retinoids. Isotrentinoin (accutane: acne treatment, normalizes epidermis cell differentiation, reduces synthesis of sebum, teratogenicity, xs intake in 1st trimester of pregnancy = congenital defects, malformations, malformed facial bones, defects in cardiac, thymus, Cns: bone development, reproduction, deficiency, 20-40 million children worldwide, low fat/plant based diets, protein-calorie malnutrition, blindness, 250,000 cases/year in children < 21 yo.