PSYC414 Lecture Notes - Lecture 10: Choline Acetyltransferase, Acetyl-Coa, Acetylcholine

• School: University of Delaware
• Department: Psychology
• Course: PSYC414
• Professor: Jeffery Rosen

Document Summary

Precursor is something we get from diet; lipid phylic cholines. Combined with acetyl coa (takes glucose and makes atp; byproduct of this) Some drugs block the transport into the vesicles (vesamicol) or block transporter from membrane (hc-3) More similarities: released; post synaptic receptors, muscarinic and nicotinic receptors, ache (acetylcholine esterase enzyme controls ach levels by breaking down choline and acetic acid. Transporter system takes up choline (takes up da and epn without metabolizing them) takes up choline to be made into ach again for the whole process to start again. Acetylcholine - acetylcholinesterase (enzyme) choline and acetic acid. Blocking transporter (hc-3) --> not remove ach from the synapse; that would be activated a lot (sensitization) Blocking vesicles inhibits reuptake into the vesicles. From botulism (bacteria from food / other things) Mechanism of action of botulinum: main nt of neuromuscular junction acetylcholine. Ach in both the sympathetic (norepinephrine released to the target organ) and parasympathetic branch (ach released to target organ)