PSYC414 Lecture Notes - Lecture 9: Fear Conditioning, Dorsal Raphe Nucleus, Tryptophan Hydroxylase
6 Mar 2018
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The serotonergic neurons of the dorsal raphe nucleus are located in the midbrain and send their axons to many forebrain areas (only a few thousand) Begins with ltryptophan (dietary amino acid- turkey) (+tryptophan hydroxylase- adds carboxyl group = 1-5- hydroxytryptophan (5-htp) (+aromatic l-amino acid decarboxylase)= 5-hydroxytrytamine aka serotonin. 6. 2 tryptophan entry into the brain and 5-ht synthesis. Ratio to amino acids and carbohydrates is weird. Tryptophan low protein // high carb diet will not interfere: decreasing in depressive patients has an effect (6. 3, relaxes you, which is why turkey makes you sleepy. Only 14 serotonin receptors in the brain. Ssris- help depression bc it leaves more of the nt in the cleft to be absorved. 6. 5 behavioral and physiological phenotypes of sert knockout mice. Knockout mice- took out the serotonin transporter: the(cid:455)"ll ha(cid:448)e too (cid:373)u(cid:272)h seroto(cid:374)i(cid:374) e(cid:448)er(cid:449)here. It works lal over: anxiety like behavior, depression, more susceptible to stress.
