PSYC414 Lecture Notes - Lecture 5: Inverse Agonist, Partial Agonist, Agonist

• School: University of Delaware
• Department: Psychology
• Course: PSYC414
• Professor: Jeffery Rosen

Document Summary

Dose response curves are in an s shape. Full agonist- starts at 0; goes to 100. Partial agonist- s curve, stops lower than 100. Partial inverse agonist- start at zero, go below the x axis. Full inverse agonist- start at zero, go to -100. Multi-state receptor models: receptor can be in multiple states like a gradient. Graph: baseline rate of behavior (high, medium, low) on y axis, ho(cid:449)s the dose respo(cid:374)se, (cid:271)ut i(cid:374) full sho(cid:449)s the falli(cid:374)g do(cid:449)(cid:374) half of the graph. Law of initial values where you are, drugs are going to have a different effect: lo(cid:449) it a(cid:272)ts as (cid:862)full ago(cid:374)ist(cid:863); i(cid:374) (cid:373)ediu(cid:373), partial effe(cid:272)t; high acts almost as an inverse agonist. The (cid:374)a(cid:373)es of the effi(cid:272)a(cid:272)(cid:455) (cid:894)i. e. , partial ago(cid:374)ist(cid:895) are(cid:374)"t fi(cid:454)ed; depe(cid:374)ds on baseline of behavior. Mix agonist/antagonist drug given to drug addicts not as a pain killer but it will have the opposite effect.