NTDT401 Lecture Notes - Lecture 13: Citric Acid Cycle, Acetyl-Coa, Pyruvic Acid
20 Dec 2016
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*do not need to remember names of enzymes (pyruvate dehydrogenase subunits) slide 21. **prosthetic groups= coenzymes lipoamide is not a vitamin is a vitamin like compound. Acetyl coa become ketone bodies with no oxaloacetate. Pdh complex mechanism explains animation and process of pyruvate dehydrogenase (slide 23-24) Needed for breaking down bcaa (leucine, isoleucine, valine) *energy & protein (amino acid) metabolism are affected. *when bcaa not metabolized, stay in body and cause maple syrup urine disease . Hexose monophosphate shunt 6 to 5 carbon conversion. Convert glucose to ribose + nadph; allows body to; 1)convert glucose to ribose for nucleotide synthesis (dna, rna: nadph as a reducing agent; prevent other compounds from being oxidized, ex. If vitamin c become deoxy** nadph reduces it back. **only need to know # for male/female adults. Female & male 1. 1-1. 2 mg/d (pay attention to unit/ rda) Dry common in adults, low level of thiamin, wasting/weak muscle. Wet water distribute improperly; retained in wrong places, edema.
