NTDT200 Lecture Notes - Lecture 5: Diabetes Mellitus Type 1, Diabetes Mellitus Type 2, Autoimmune Disease

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Patients have a problem with regulating blood glucose (sugar) Can cause complications and damage to other body functions if not monitored and controlled. Pancreas secretes insulin in response to increased blood sugar. Stimulates cells to take up glucose from the blood. Promotes extra glucose to fat in liver and adipose. Pancreas secretes glucagon in response to decreased blood sugar. Stimulates liver to release glucose into the blood. Type 1 diabetes mellitus: muscle and adipose cannot take up glucose. 9 out of 10 people with diabetes have type 2. Used as energy source instead of muscle protein. Injections discovered in 1921 by dr. banting who injected it into dogs. Oral glucose tolerance test (ogtt) 140 to 199 mg/dl. Occurs because of high blood sugar during pregnancy. Pregnancy hormones cause insulin resistance: heart, blood vessels, kidneys, nerves. Extra fuel and insulin causes infant to grow.

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