BISC306 Lecture Notes - Lecture 7: Clathrin, Endocytosis, Muscarinic Acetylcholine Receptor

• School: University of Delaware
• Department: Biological Sciences
• Course: BISC306
• Professor: Cain William

Document Summary

9/21/16: neurotransmitters, acetylcholine-huge motor end plate synapse a. i. Lots of chlorine outside of cell=acetylcholine as inhibitor; close to acetylcholine equilibrium potential a. ii. Less chlorine outside of cell=acetylcholine as excitatory a. iii. Signal terminated: acetylcholine is removed from the synaptic cleft by digestion with the enzyme acetylcholine esterase a. iv. Acetylcholine esterase-breaks down acetylcholine in the neuromuscular junction synaptic cleft b. Many neurotransmitters may be digested by an enzyme in synaptic cleft b. ii. Be removed by uptake into the presynaptic neuron or glial cells b. iii. Simply diffuse away: synaptic transmission is sometimes inhibitory c. i. Decreases probability of action potential: neuronal synapses-much smaller synapses d. i. Gaba & glycine=main inhibitory neurotransmitters; create small hyperpolarizing responses; let cl- into cell d. ii. Neurotransmitter release: (classical & kiss-and-run models: classical model, targeting, docking, priming, fusion, endocytosis: clathrin as protein that helps the capsule form a sphere all the contents or none of it, kiss-and-run model.