BISC300 Lecture Notes - Lecture 15: Signal Transduction, Lac Repressor, Histidine
27 Feb 2018
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10:15 pm: purple= things said in class, not on slides. Describe mechanisms by which translation can be regulated. Describe how multiple sets of genes can be controlled by a single signal, i. e. global regulation. Explain the importance of secondary messengers, protein phosphorylation and alternative sigma factors in global regulation. Describe diauxic growth in terms of gene regulation. The way it works is usually to obscure the sd site. Patch in 5" untranslated region of mrna that is complementary to the end of the 16s ribosomal rna - says "ribosomes bind here" If this site is not open in a ss conformation, ribosomes can"t see it - cant access it. Riboswitches in gram-negative bacteria regulate translation of mrna. Effector binding elements at 5" end alters mrna leader folding pattern. Secondary structures in rna - they are ways that a ssrna molecule can fold up on itself productively - you get small regions of dsrna.
