BISC300 Lecture Notes - Lecture 16: Yellow Fever, Flavivirus, Innate Immune System
15 Dec 2016
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Document Summary
Flaviviruses: flavivirus refers to members of the family flaviviridae, flaviviridae and flaviviruses are named after yellow fever virus, because this virus causes jaundice (flavi is latin for yellow) Old red blood cells travel to your liver, where they"re broken down. Bilirubin is the yellow pigment formed by the breakdown of these old cells. Packageable genomes: viroplasms allow it to hide itself from host cell antiviral defenses. Go to rer and translated some in er and some in cytoplasm; Enter macrophages and dendritic cells; immune response cells. Have untranslated regions at both ends; interact with proteins for copying genome: 3" is much more complicated, have stem loop structures involved in packaging. Genome encodes one giant protein 1 continuous protein: has structural and non structural parts. Structural: glycoproteins, capsid protein this is the 5" end. Virus controls how much it makes of everything by the efficiency of translation: make more of structural proteins bc the virus needs them more.
