BISC300 Lecture Notes - Lecture 9: Hiv, Antigenic Drift, Reassortment
27 Nov 2016
School
Department
Course
Professor
Document Summary
Bisc300 mechanism of viral diversity lecture notes: ex: herpes dsdna virus, rna virus is where we see a lot of genetic diversity. Molecular mechanism of genetic diversity: error proness of rna-dependent-rna-polymerase, reassortment. Outcomes of viral genomic diversity: antigenic drift due to accumulation of mutations in a strain within a geographic area. Acquired immune deficiency syndrome (aids: caused by human immunodeficiency virus (hiv) Pandemic with uncertain origin: hiv-1 evolved from chimp virus sivcpz. Only group m hiv-1 is widespread in u. s. I(cid:374)tegrates i(cid:374)to host (cid:272)ell"s dna as a provirus: can remain latent asymptomatic, chronic infection-symptomatic, can direct synthesis of viral rna synthesis of new viral particles. New virion are assembled and released through budding and eventual lysis influenza: respiratory system disease caused by influenza virus. Negative rna virus; segmented genome (8 ssrnas) Acquired by inhalation or ingestion of respiratory secretions: 31 possible pandemics, worst pandemic in 1918 killed ~50 million people, 8 genomes.
