BISC300 Lecture Notes - Lecture 12: Acute-Phase Protein, Reactive Oxygen Species, Lectin
27 Nov 2016
School
Department
Course
Professor
Document Summary
Competitive activation: produced in inactive forms, activated following enzymatic cleavage, must be activated in cascade fashion. Opsonization: process in which microbes are coated by serum components (opsonins) in preparation for recognition/ingestion by phagocytic cells, some complement proteins are opsonins. Bind to microbial cells, coating them for phagocyte recognition. Cytokines: soluble proteins or glycoproteins that are released by 1 cell pop that act as intercellular mediators or signaling molecules, 3 proposed groups based on func regulators of innate resistance mechs regulators of adaptive immunity. Stimulators of hematopoiesis: cytokine production is induced by nonspecific stimuli (infection), inflammation, t cell-antigen interactions, autocrine func. Affect same cell responsible for their production: paracrine func. Spread by circulatory system to distant target cells. Acute phase proteins: macrophage activation by bacteria causes cytokine release, liver stimulation, acute phase protein production includes c-reactive protein (crp), mannan-binding lectin (mbl), surfactant proteins a (sp-a) and d (sp-d) Degradative enzymes, toxic reactive oxygen intermediates (rois), reactive nitrogen intermediates (rnis)
