BISC207 Lecture Notes - Lecture 13: Oxaloacetic Acid, Citric Acid Cycle, Atp Synthase

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BISC207 Full Course Notes
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BISC207 Full Course Notes
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Metabolic pathway: a coordinated sequence of chemical reactions. Each step is typically catalyzed by a single unique enzyme. Catabolic reactions/pathways : breakdown molecules and store energy atp. Anabolic reactions/pathways : use energy to build molecules. Net gain of 2 atp and 2(nadh + h proton) Energy investment, cleavage (6 carbon compounds go to 2 g3p), to energy liberation (2 g3p to 2 molecules pyruvate, 4 atp and. Substrate level phosphorylation forms atp in glycolysis, a phosphate group is directly transferred from a donor molecule to. Glycolysis is regulated at the 3rd step by feedback inhibition of phosphofructokinase. Phosphofructokinase has 2 atp binding sites, regulatory site has a lower affinity for atp. Atp binding at the regulatory site slows the reaction rate; atp binding at active site catalyzes 3rd step of pathway. Affinity is how tightly molecules bind to each other. Pyruvate processing / breakdown (or acetyl co-a synthesis)

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