ANFS332 Lecture Notes - Lecture 22: Viral Shedding, Intestinal Villus, Parvovirus
27 Nov 2016
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Document Summary
Canine parvovirus: parvoviridae family, linear, non-segmented single stranded dna, small size: 20-23nm, non-enveloped. Indirect transmission of cpv occurs from contact with feces and fecal- contaminated objects: cpv can be shed in dog feces for up to 3 weeks after infection, after recovery, dogs may become carriers, shedding virus periodically. Infected lymphocytes die and wbc in bone marrow die: 3-4 days after infection, virus particles are shed in the feces and continue to be shed for up to 3 weeks, virus infects epithelial cells of the small intestine. Infects cells of the crypts of lieberkuhn place where the short-lived intestinal epithelial cells are produced: eventual collapse of intestinal villi and epithelial necrosis result from viral replication in intestinal epithelial cells. Clinical findings: cpv2 gastroenteritis, most common in pup 6-20 weeks old, acute onset of lethargy, loss of appetite, fever, vomiting and diarrhea, diarrhea may contain mucus or blood, common complication: pulmonary edema or alveolitis, death rate 16-48%
