ANFS251 Lecture Notes - Lecture 10: Endocytosis, Intracellular Parasite, Phagocytosis
12 Sep 2017
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Document Summary
Antibody diversity review mhc and cellular immunity: the immune system has the capacity to recognize and respond to about 10^7 different antigens. This extreme diversity can be generated in at least three possible ways: multiple genes in the germ-line (stem cell) dna, variable recombination during the differentiation of stem cells into b cells, mutation during differentiation into b cells. Antibody affinity and clonal selection: the strength of the interaction between an antibody and its specific antigen is called the binding affinity of the antibody. The higher the affinity, the tighter the association between antigen and antibody. Antibody affinity generally increases with repeated exposure to antigen because b cells with higher affinity antigen receptors are selected to produce larger clones of antibody-secreting plasma cells. His process is part of clonal selection and also involves mutations. Cytotoxic t lymphocytes (ctl) recognize foreign antigens on target cells and kill the infected cell.
