AGRI 224 Lecture Notes - Lecture 22: Dengue Virus, Adoptive Cell Transfer, Serotype

• School: University of Delaware
• Department: Agriculture
• Course: AGRI 224
• Professor: Aresenault

Document Summary

Protective efficacy of multiple vaccine platforms against zika. Monkey will respond with antibodies, if infected later they have antibodies. Injecting antibodies - not developing antibodies itself passive. Inject dna to a protein of the virus - dna will get into cells and replicate. Neutralizing antibodies bind to the surface proteins of a virus to block infection. Ade occurs when antibodies that neutralize one virus can bind to, but do not block the infection of, a similar virus. Bind slightly to it, which protects virus from immune system and helps it infect. You"ve made the virus immune to you - shielded by the antibody to a similar virus. Ade is most commonly observed for dengue virus. There are 4 serotypes of dengue virus, which contain closely related but distinct surface proteins. Infection with one serotype typically results in mild symptoms. This can result in a more severe form of disease such.