PSYC 181 Lecture Notes - Lecture 3: High-Throughput Screening, Psychiatric Medication, Profit Margin
Document Summary
Outline of drug development: discern unmet medical need (bio or marketing research, biology, discover mechanism of action of disease. *identify target protein: chemistry, screen known compounds against target, computerized algorithm screens for safe, lipid soluble drugs that won"t interact with proteins in the body, chemically develop promising leads. *find 1-2 potential drugs: pharmacology, toxicity, pharmacology. Naturally occuring: example: ephedrine: ma-huang plant, cocaine: coca leaves, opium: from unripe seeds of the opium poppy, 2. Synthetic: made in lab, examples: methadone (synthetic opiate, amphetamine (powerful stimulant, opium, morphine, heroin, methadone, naming pharmaceuticals, chemical name, not enough to produce drug bc structure usually needed, manufacturer"s laboratory designation. Important bc sometimes drugs do not get approved and don"t get actual names: chemical group name. Intramuscular (i. m. : slowest, muscle is dense, hard for liquid to get out, lasts long time, bad for muscle. Intravenous: fastest way, reaches within 10 seconds even brain.
