PSYC 108 Lecture Notes - Lecture 10: Reuptake, Methylphenidate, Effect Size
Document Summary
Adhd, catecholamines and pharmacology, dopamine and noradrenaline, both are catecholamines, made from tyrosine - from diet, dopamine transmission, tyrosine -> dopa -> dopamine -> d1 and d2 postsynaptic receptors, na transmission. Similar to da: except noradrenaline binds to alpha-2a-adrenoceptors, dopamine projection pathway, nigrostriatal pathway. Substantia nigra to striatum: degenerates in parkinson"s, motor control, mesolimbic pathway, ventral tegmental to limbic system, mesocortical pathway, ventral tegmental to cortex, prediction error pathway, tells the cortex there was an error in prediction, noradrenaline projection pathway. Located in the brainstem: project to a bunch of places, very wide spread, adhd, diagnosis, uses the dsm v, requires 5 criteria to reach diagnosis (a-e) Shows there"s a developmental/genetic component and not environmental: could be inattention or hyperactivity/impulsivity, other aspects, prevalence: 5-10, comorbidity: ocd and tourette"s syndrome, persists into adulthood, heritability index: 0. 77 --> high! Looked at frontal, striatum , midbrain: and used occipital as reference.
