COGS 107A Lecture Notes - Lecture 6: Lipid Bilayer, Nernst Equation, Goldman Equation
28 Dec 2016
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Document Summary
Differentiate the resting membrane potential from the action potential. Describe the means for encoding information in the activity of neurons. Understand that electrical signaling is the fundamental process that underlies all aspects of brain function. Equilibrium potential: membrane potential at which there is no net movement of one permeant ion. You need: channels (something that goes back and forth) & membrane & ions. Electrostatic pressure coupled with the concentration gradient to get equilibrium point. Ion channels can be open, close, leaky, specific, etc. Ions can only diffuse by passing through channels. Ex: 1mmkcl: same [k+] on each side. When [k+] is not the same in both compartments: concentration gradient. Electrostatic pressure exactly balances with diffusion = equilibrium potential. What is needed for eq potential: channels. These are of different varieties [open, closed, specific, and leaky] Ions: dependent on temperature, valence, concentrations, permeabilities, etc. There are different membrane equilibrium potentials for different neurons. Nernst equation units: joules/coulomb [same as for volts]
