PNB 2265 Lecture Notes - Lecture 12: Ventral Respiratory Group, Medulla Oblongata, Carotid Body
16 Aug 2018
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Document Summary
Lungs are designed to bring oxygen close to blood. Blood is designed to transport oxygen everywhere and bring co2 back to the lungs to get rid of it. Anesthetic gases halogenated ethers: equilibrate rapidly, perfusion limited more gas greater effect, effect is gone as soon as you stop perfusion, do not chemically interact with blood proteins. Co2 and o2: chemically combine with blood, diffusion limited. Oxygen is about 200 ml/l blood: = 100 mmhg. Hb: both oxygen and co2, oxygen to heme moiety, easy on, easy off, co2 to amino acids, large absorption of gases without changing partial pressure. Oxygen transport: 98. 5% by hb lungs hhb+oxygen = oxyhb + h+ (msec, tissures oxyhb + h+ = hhb + oxygen (msec) Hb affinity: affect by po2, ph, pco2, co, no, cyanides. When blood passes through the alveoli hb 100% saturated with oxygen. Venous blood returning to heart, hb 75% saturated with oxygen.
