PNB 2265 Lecture Notes - Lecture 24: Glutathione, Smooth Muscle Tissue, Caffeine

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Digestion: proteins: endopeptidases, attack peptide bonds to break protein into fragments in the middle, stomach secretions (e. g. pepsin, pancreatic secretions (e. g. trypsin, small intestine peptidases, exopeptidases, release single amino acids, mostly pancreas (e. g. carboxypeptidase, cuts towards the end. Absorption: fats: apical membrane, monoglycerides & fa -> diffusion, cholesterol -> transporter. Inside cells: chylomicrons form, basolateral membrane, exocytosis, lipases are water soluble, so only have access to what is on the surface. Be good to your liver : alcohol dehydrogenase, converts etoh to acetylaldehyde, acetylaldehyde, toxic (headaches, vomiting, carcinogenic, makes you feel miserable after drinking, acetylaldehyde dehydrogenase & glutathione (detoxifies other compounds) Break down acetaldehyde: if you are drinking and taking tylenol, youre just going to break down tylenol instead of the acetylaldehyde which is damaging, we only have so much of these enzymes available. Phases of integrated meal response: cephalic phase, gastric phase, intestinal phase, colonic phase.

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