PNB 2265 Lecture Notes - Lecture 20: Pulmonary Edema, Perfusion, Chronic Obstructive Pulmonary Disease
6 Mar 2017
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Exchange: emphysema affects, thickness of respiratory membrane increased, surface area for exchange decreased, pulmonary edema also impedes gas exchange. Transport of respiratory gases by blood: oxygen transport, small amount dissolved in plasma (giving out po2, 98. 5% carried on hemoglobin, hb greatly increases the amount of o2 that can be carried in the blood, hhb+o2 hbo2+h. Hemoglobin-oxygen dissociation curve: po2 determines whether oxygen binds to hb or is released from hb, cooperative binding, affinity of hb for o2 varies with oxygen saturation, % saturation at arterial blood and tissue po2 values. Oxygen movement in lungs and tissues: hb wants o2, so it detaches co2. Factors shifting hbo2 curve: understand what right and left shifts do to % saturation, cadet. Co2 transport: co2 entering blood from tissues is transported by one of three ways, dissolved in plasma, gives us out pco2, bound to hb, carbaminohemoglobin, allows o2 to come off, co2 to come on.
