PNB 2265 Lecture Notes - Lecture 7: Pacemaker Potential, Cardiac Muscle Cell, Active Transport

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The cardiac muscle attaches to a fibrous skeleton. Gives muscle tissue something to build off of. Fibrous ct (not good conductor of electricity) May have 2 nuclei (fibers are shorter, only 1 or 2) Create the atrial and ventricular syncytia making cardiac muscle a single motor unit. Desmosomes - buttons on pants (physical connection at point of stress) Gap junctions - forks that connect membranes, electrical connection between neurons. No ap in heart for muscle fiber to contract. Ap t tubule dhp opens ca2+ released troponin tropomyosin muscle contraction. Dhp receptor = functional voltage gated ca2+ channel. Allows ca2+ ions to come into cell. There is more ca 2+ in cardiac muscle than skeletal. Cardiac myocytes increase sensitive to external concentrations of. Cardiac contractility = proportional to the ca2+ signal. Na+ concentration needs to lower inside cell. Hcm t channels l channels peak ik (potassium channels) .

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