NURS 3110 Lecture Notes - Lecture 15: Amphotericin B, Cytochrome P450, Proton-Pump Inhibitor
Document Summary
Antifungals: learning objectives: take months to cure. Pharmacology basics: how drugs and biologics act on the human body. Includes kinetics (absorption, distribution, metabolism and elimination) and dynamics (how the drug binds to cause an action: limitations to drug development, researchers look for drugs and biologics that have little, if any, impact of drugs on human cells. Example: antifungal amphotericin b binds to ergosterol in cell membrane. Important intracellular actors: exist in plants, insects, fish, mammals and microorganisms, different types in various tissues: liver, kidney, lungs, brain, very important in drug metabolism, differentiate between, substrates, needs cytochrome to be metabolized. Inhibits the system so any other drug metabolized is going to have problems: some drugs are inhibitors while other induce and other do both. Cyp in the liver: p450 3a most important, 2d6, 2c19. Two main types of antifungals: polyenes: kidney, amphtericin, nystatin, azoles: liver, ketoconazole, fluconazole.
