MCB 2210 Lecture Notes - Lecture 26: Centromere, Interphase, Maturation Promoting Factor

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Cell cycle: ordered series of events that leads to cell duplication and division: m-phase (mitosis/meiosis) small fraction of the cycle, interphase the rest of the cell cycle. G1-phase (gap 1) period between the completion of previous mitosis and the initiation of dna synthesis for the next mitosis. Some cells exit the cell cycle into a post-mitotic, non- proliferating state g0 (g zero) G2-phase (gap 2) period between the completion of dna replication and the initiation of mitosis. The cell cycle is tightly regulated: progression relies on cell growth and successful passage through several checkpoints. Ensures the accuracy and fidelity of chromosome replication. Chromosome replication and cell division must occur in the proper order and proper time in every cycle: in many cells, growth and division rates are coupled. The two processes can be regulated independently as well. Cell size is determined by the rate of growth and duration of the cell cycle.

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