MCB 2210 Lecture Notes - Lecture 21: Cell Adhesion Molecule, Adherens Junction, Intermediate Filament
17 Dec 2018
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Document Summary
Cells in tissues interact with one another and with the extracellular environment. Connections are used to allow cells to aggregate into tissues. Bidirectional transfer of info between the exterior and interior of the cell. Communication used for cell survival, proliferation, differentiation and migration. Cell-cell adhesion - direct adhesion through cell adhesion molecules. Cell adhesion molecule (cams) - transmembrane proteins to directly connect cells in tissues. Cell-matrix adhesion - indirect adhesion between adhesion receptors and extracellular matrix. Adhesion receptors - transmembrane receptors used to indirectly connect cells in tissues by binding to components of the extracellular matrix. Ecm - complex meshwork of proteins and polysaccharides secreted by cells into extracellular spaces. Tight junctions - seals gap between epithelial cells. Adherens junction - connects actin filament bundle in one cell with that in the next cell. Desmosome - connects intermediate filaments in one cell to those in the next cell.
