BIOL 3402 Lecture Notes - Lecture 6: Central Chemoreceptors, Hypothermia, Brainstem
Document Summary
Hypothermia (curve moves left: less oxygen unloaded, temperature below 37c. Fever (curve moves right: promotes oxygen binding/unloading ph dissociation. Rate and depth adjust to maintain levels. Brainstem respiratory centers: central/peripheral chemoreceptors monitor csf and blood, ph, carbon dioxide, oxygen. Pulmonary ventilation is adjusted to maintain ph of the brain: central chemoreceptors in medulla produce about 75% of change in respiration induced by ph shift. Hydrogen ions also stimulate peripheral chemoreceptors which produce 25% of the respiratory response to ph changes. Hypocapnia po2 less than 37 mmhg: most common cause of alkalosis. Hypercapnia po2 greater than 43 mm hg: most common cause of acidosis. Respiratory acidosis & alkalosis ph imbalances resulting from a mismatch between the rate of pulmonary ventilation and the rate of carbon dioxide production. Hyperventilation can be a corrective homeostatic response: reverse acidosis, blow off carbon dioxide, reduces acid, raises ph. Ketoacidosis rapid fat oxidation: metabolic acidosis, low carb, diabetes, induces kussmaul respiration.
