BIOL 3402 Lecture Notes - Lecture 2: Ferritin, Folic Acid, Erythropoiesis
Document Summary
4 protein chains = globins: adult hb has 2 beta chains and 2 alpha chains, fetal hb has 2 alpha chains and 2 gamma chains, globins bind co2. 4 heme groups: nonprotein moiety that binds o2 to ferrous ion (fe) at its center. Rbc count and hemoglobin concentration indicate amount of o2 blood can carry: hemocrit (packed cell volume): % of whole blood volume composed of rbcs. Values lower in women: androgens stimulate rbc production, menstrual losses, hematocrit is inversely proportional to % of body fat. Erythropoiesis (rbc production: 1 million produced per second, lifespan of 120 days, development takes 3-5 days. Reduction of cell size, raises cell number, synthesis of hemoglobin, lose nucleus: 1st committed cell signal. Key nutritional requirement: lost through urine, poop, blood, low absorption rate, requires 5-20 mg/day, gastroferritin & transferrin. Transport iron: liver apoferritin = storage. Vitamin b12 & folic acid: rapid cell division & dna synthesis.
