SOC GEN 5 Lecture Notes - Lecture 4: Antimicrobial Resistance, Net Profit, Antibiotics
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3 notes: characteristic of all microbes, including bacteria, archaea, and fungi, bacteriophages (transduction) Virus picks up bacterial chromosome while reproducing itself using bacteria"s cellular mechanism. Can also integrate in bacterial chromosomes and cause lysis later same result: transformation. When bacteria becomes competent enough to accept foreign dna. When bacteria undergo stress and is forced to. In sum: bacteria is not just an individual species, but a vast array of interacting constituents of an integrated microbial world. Antibiotics in an environment are a selective pressure. Gene transfer must be integral and critical to the overall survival of bacteria, providing a way for them to adapt to difficult conditions. Any virulence or resistance factors (clusters) must be advantageous. Antibiotics can affect many people surrounding a patient by creating an environment w/ antibiotics as a selective pressure. The environment is dangerous w/ the presence of pathogens, but antibiotic-resistant bacteria themselves may not be pathogenic. Hospital-acquired infections and horizontal gene transfer (nosocomial)
