PHYSCI 121 Lecture Notes - Lecture 31: Glycan, Golgi Apparatus, Lipid Bilayer
Document Summary
Glycans are abundant on the surface of cells. Although this specific example is one of a fibroblast cell, the muscle cell would be no different. The lipid bilayer in a muscle cell (sarcolemma) will also have the same carbohydrates on the cell surface. Understand that there are many classes of them. Glycan structure is added to the er and goes through the golgi apparatus to be elongated. End glycans are the same size as the main glycan itself. A long chain like protein modified with o-glycans. Stepwise fashion, each set has a different set of enzymes. Looking at these steps show dozens of red genes that participate in making the precursor, and add it to the protein. Used this to find out about the enzymes. Glycosylation of cellular and secreted proteins and lipid is deficient or defective. Cdg syndromes typically cause severe, sometimes fatal, malfunction of different organ systems.
