PHYSCI 121 Lecture Notes - Lecture 30: Deflazacort, Prednisone, 10-Meter Band
Document Summary
Physical therapies and outcomes for dmd patients part 3. Natural history studies: how does a measurement change over time, outcome measurements are critical for fda approval, most clinical trials use simple clinical tests. Steroids (prednisone and deflazacort) inflammation and are the standard of care. Functional loss doesn"t typically begin until 7 years old. >12 sec: require a wheelchair within 1 year. Children, with or without dmd, improve in this measure between 4 and 7 years of age. Cerebral palsy is a group of permanent movement disorders that appear in early childhood. Palsy is caused by abnormal development of the brain that controls movement, balance, and posture. 3-d gait analysis: commonly used to study cerebral palsy, gait labs are expensive, more common in large pediatric hospitals, precise measurements of movement during walking. Staffed by experienced researchers, therapists and engineers: proximal weakness, ankle compensates for weak hip, disease progression. Lumbar lordosis: weakness: line of gravity moves.
