PHYSCI 121 Lecture Notes - Lecture 19: Nitric Oxide Synthase, Cgmp-Specific Phosphodiesterase Type 5, Nos1
Document Summary
No-cgmp pathway as a new drug target for muscular dystrophy. Pde5 inhibitors (or no donors) improve muscle blood flow in bmd and dmd. Will better blood flow preserve muscle? nnosm = neuronal nitric oxide synthase: muscle-specific sarcolemmal targeting by dystrophin (sr16/17, main source of no, muscle blood flow. Sympathetic system turns on in the brain and releases endorphins to relaxing muscles to help them contract. Metabolism is produced by the exercising muscle that activates nnos signaling. Gnp dependent process where downstream signaling is attenuated. Prevents the nerve from chocking up the blood supply of the working muscle, that"s why they call it. Doppler flow probes help to measure bloodflow in relatively inaccessible areas with limited clearance and soft tissue. Rat"s contractions are examined during rest and physical activity. Increase in blood pressure and decrease in blood flow is basic constriction. Hyperemia - an excess of blood in the vessels supplying an organ or other part of the body.
