MIMG 102 Lecture Notes - Lecture 18: Dna Virus, Reverse Transcriptase, Cd46
20 Mar 2019
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Document Summary
Can be small (5kb) or very very large (2000 kb) Most replicate in the nucleus: +ssdna tend to have small genomes (<10 kb) and have few genes. Genome potentially unstable (less protected as ssdna: group 7: mix of retro virus & dsdna virus. Contain dsdna genome with a ssdna region. Packaged dna is stable, rna genome is unstable (focus on group 1 for now) Stuff dna viruses do that rna viruses often do not: transport of viral dna into nucleus. Also: dna in cytoplasm get recognized by cell as viral infection -> interferon & other stuff. Initiation of transcription directly from imported dna: transcriptional cascade temporally regulates viral replication, drive cells into s phage to facilitate replication of viral dna genome in nucleus. Turns host mechanism on: packaging of dna into virions & egress from nucleus. Genome: polyomaviridae & papillomaviridae: circular dna, 1 ori, replicate bi-directionally, adenoviridae: linear, 2 ori at both ends.
