MIMG 102 Lecture Notes - Lecture 21: Viral Envelope, Herpesviridae, Dna Replication

• School: UCLA
• Department: Microbiology, Immunology, and Molecular Genetics
• Course: MIMG 102
• Professor: Dasgupta Asim

Document Summary

Contains 20 viral protein species (plus host proteins) Delivers free, already-formed new proteins into infected cell. Ordered assembly during and post nuclear egress, helps build envelope & hold envelope together. Inner: specific protein names that don"t matter. Outer: many proteins specific for each virus & cell type it infects. Specific viral proteins in inner & outer tegument: glycoproteins on envelope: important for binding cells, herpesvirus portal pumps dna in & out of capsid, herpesvirus genome large dsdna genome. Genome has unique long (ul) and unique short (us) regions flanked by repeats (r) (have terminal repeat. Most of the 41 conserved genes found in sequence blocks conserved gene mainly in 6 blocks code for: Nucleotide metabolism: thymidine kinase, ribonucleotide reductase etc. Immune evasion: often specific for each family. Infection: two mechanisms: productive infection & latent infection (dormant; waits) Latent infection might reactivate into productive infection: productive. Immediate early, early (dna replication, commitment to productive growth), late gene expression.